Dietary 3'-sialyllactose reduces sensitization and type 2 inflammation in a house dust mite induced acute allergic asthma model
Dietary 3'SL and 6'SL showed dose-dependent, differential clinical and immunological outcomes in HDM-sensitized mice. Both 0.5% 3'SL, 0.1% 6'SL, and 0.5% 6'SL reduced airway hyperresponsiveness. However, 0.5% 6'SL increased eosinophilic inflammation, while 3'SL protected against HDM-induced sensitization and asthma development.
Authors
- Johan Garssen (ORCID: https://orcid.org/0000-0002-8678-9182)
- Belinda van’t Land (ORCID: https://orcid.org/0000-0001-8601-5032)
- Marleen Zuurveld
- Gert Folkerts (ORCID: https://orcid.org/0000-0003-0630-2192)
- Atanaska I. Kostadinova
- Linette E. M. Willemsen (ORCID: https://orcid.org/0000-0001-9882-5331)
- Janna W. M. de Kleer
- Ingrid van Ark
- A. Leusink-Muis
Institutions
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- Danone (Netherlands) (NL)
Publication Details
- Journal
- Frontiers in Allergy
- Published
- 2025-12-01
- DOI
- https://doi.org/10.3389/falgy.2025.1604917
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universiteit Utrecht