Estradiol enhances B cell humoral immune responses against genital herpes simplex virus type 2 in mice through an IL-17 dependant pathway
This study provides novel evidence that part of the E2-induced enhanced anti-viral response is mediated by increased B cell antibody responses that requires IL-17. Thus, E2 could be exploited in developing an effective mucosal vaccine driving B cells through intranasal immunization to elicit stronger HSV-2-specific antibody responses in the female genital tract.
Authors
- Puja Bagri
- Maysa Niazy
- Joshua J.C. McGrath (ORCID: https://orcid.org/0000-0002-9267-5501)
- M. Firoz Mian (ORCID: https://orcid.org/0000-0001-6846-9794)
- Ramtin Ghasemi
- Denis P. Snider (ORCID: https://orcid.org/0000-0002-4285-4982)
- Charu Kaushic
- Danya Thayaparan
Institutions
- McMaster University Medical Centre (CA)
- McMaster University (CA)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.3389/fimmu.2025.1691163
- Citations
- 1
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Canadian Institutes of Health Research