Impact of individualized tidal volume strategies on intraoperative lung protection and inflammatory markers in laparoscopic cholecystectomy: a randomized controlled trial

Individualized tidal volume settings were associated with significantly lower postoperative elevations of IL-6, TNF-α, HTI56, and SP-A compared to conventional settings. These findings suggest that tailoring tidal volume based on resting respiratory parameters may help mitigate lung capillary barrier injury by attenuating the inflammatory response, thereby enhancing pulmonary protection during mechanical ventilation.