Unveiling the Potential Mechanism of Asymmetric Fat Infiltration in Paraspinal Muscles of Adult Degenerative Scoliosis: The Role of the Hsa_circ_0006156/ <scp>miR</scp> ‐122‐5p/ <scp>PPARA</scp> Regulatory Network
Paraspinal muscles in ADS patients show marked fat infiltration with lateral asymmetry, especially on the concave side. hsa_circ_0006156 regulates lipid metabolism through the miR-122-5p/PPARA axis and reduces fat deposition, providing a potential molecular target for early diagnosis and intervention in ADS-related muscle degeneration.
Authors
- Jun Shu
- Liejin Guo (ORCID: https://orcid.org/0009-0003-2257-3109)
- Xueneng Yang (ORCID: https://orcid.org/0009-0004-4760-4511)
Institutions
- Kunming Medical University (CN)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-11-30
- DOI
- https://doi.org/10.1002/jsp2.70146
- Primary Topic
- Scoliosis diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00