Dual-locked targeted alpha-emitter enhanced tumor immunotherapy via Diels–Alder reaction-based self-immolative molecular cage strategy
These findings underscore the potential of dual-locked pretargeted strategies to advance TAT by improving therapeutic efficacy and addressing the critical challenge of radionuclide leakage, paving the way for next-generation precision-targeted radiopharmaceuticals.
Authors
- Fei Yu (ORCID: https://orcid.org/0000-0003-2951-725X)
- Shanshan Qin (ORCID: https://orcid.org/0009-0003-1722-0392)
- Shuo Shi (ORCID: https://orcid.org/0000-0003-4387-3445)
- Rong Rong (ORCID: https://orcid.org/0000-0003-2423-4082)
- Kang Fang (ORCID: https://orcid.org/0000-0002-8233-1182)
- Mengdie Yang (ORCID: https://orcid.org/0000-0002-6390-2728)
- Gang Yang (ORCID: https://orcid.org/0000-0002-9699-7014)
- Xiaoyi Zhang (ORCID: https://orcid.org/0000-0002-7428-1058)
- Le Cai (ORCID: https://orcid.org/0000-0001-9912-8423)
- Xinda Yang (ORCID: https://orcid.org/0000-0002-9337-9878)
- Hongyi Yi
Institutions
- Tongji University (CN)
- Shandong University of Traditional Chinese Medicine (CN)
- Zhejiang Cancer Hospital (CN)
- Shanghai Tenth People's Hospital (CN)
Publication Details
- Journal
- Military Medical Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s40779-025-00673-5
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00