Cellular characteristics of the immune microenvironment of colorectal cancer and progress in immunotherapy research
Special consideration is directed toward the translational value of targeting immune-metabolic interactions and spatial dynamics within the TME. Ultimately, this work synthesizes current knowledge and outlines forward-looking strategies to advance personalized, multi-target immunotherapy, with the potential to reshape clinical paradigms in CRC management.
Authors
- Xinran Cao (ORCID: https://orcid.org/0009-0002-6609-7960)
- Chunbaixue Yang
- Yixuan Zhang (ORCID: https://orcid.org/0000-0003-3620-0509)
- Jianchun Fan (ORCID: https://orcid.org/0000-0003-4570-6018)
- Yixiao Zhang (ORCID: https://orcid.org/0009-0005-5957-1611)
- Lei Xia (ORCID: https://orcid.org/0000-0003-2671-8347)
- Xueliang Wu
Institutions
- Hebei Medical University (CN)
- Hebei North University (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-11-30
- DOI
- https://doi.org/10.1080/07853890.2025.2591308
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00