Solvent‐Assisted Efficient Syntheses of 1,3,5‐Triaryl‐1 <i>H</i> ‐Pyrazoles via Ring Opening and Cyclization in Chalcone Epoxides
ABSTRACT Solvent‐assisted ring opening and subsequent cyclization of chalcone epoxides with hydrazine derivatives is reported under mild reaction conditions. Various 1,3,5‐triaryl‐1 H ‐pyrazole derivatives were synthesized in good to excellent product yields with functional groups tolerance. The reaction was also performed for the gram scale transformation in excellent product yield (84%). The structure was confirmed by 1 H & 13 CNMR, IR, HRMS, and SC‐XRD analysis.
Authors
- Avijit Bhakta (ORCID: https://orcid.org/0009-0005-3252-0216)
- Naseem Ahmed (ORCID: https://orcid.org/0009-0007-7264-7339)
Institutions
- Indian Institute of Technology Roorkee (IN)
Publication Details
- Journal
- ChemistrySelect
- Published
- 2025-11-30
- DOI
- https://doi.org/10.1002/slct.202505920
- Primary Topic
- Microwave-Assisted Synthesis and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Indian Institute of Technology Roorkee
- Ministry of Education, India