Generalisability of Maternal Genetic Risk Score for Birth Weight Across Racial Identity and Ancestry: A Secondary Analysis of a Prospective Cohort Study

This GRS<sub>BW</sub> is not generalisable across self-described racial identities or GPA groups, highlighting the need for globally representative genetic discovery cohorts as well as further investigation into the complex role of race, ethnicity, and epigenetic influences on foetal growth.

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Publication Details

Journal
BJOG An International Journal of Obstetrics & Gynaecology
Published
2025-11-30
DOI
https://doi.org/10.1111/1471-0528.70088
Primary Topic
Birth, Development, and Health
Type
article
Field-Weighted Citation Impact
0.00

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article

Generalisability of Maternal Genetic Risk Score for Birth Weight Across Racial Identity and Ancestry: A Secondary Analysis of a Prospective Cohort Study

Jon G. Steller, Maryam Zeinomar, Nathan R. Blue, Michelle P. Debbink et al.
BJOG An International Journal of Obstetrics & Gynaecology
Birth, Development, and Health
article

Generalisability of Maternal Genetic Risk Score for Birth Weight Across Racial Identity and Ancestry: A Secondary Analysis of a Prospective Cohort Study

Jon G. Steller, Maryam Zeinomar, Nathan R. Blue, Michelle P. Debbink, David M. Haas, Tsegaselassie Workalemahu, Lisa M. Pappas, Rafael F. Guerrero, Joseph R. Mims, Bita Tristani‐Firouzi, Merry Joseph, George R. Saade, Barry Moore, R.M. Silver
article en

Abstract

This GRS<sub>BW</sub> is not generalisable across self-described racial identities or GPA groups, highlighting the need for globally representative genetic discovery cohorts as well as further investigation into the complex role of race, ethnicity, and epigenetic influences on foetal growth.

BJOG An International Journal of Obstetrics & GynaecologyVol. 133(4)
Intermountain Healthcare (US), North Carolina State University (US), Eastern Virginia Medical School (US), University of California, Irvine (US), University of Utah (US), University of California, Irvine Medical Center (US), Indiana University Indianapolis (US), Indiana University – Purdue University Indianapolis (US)
University of Utah, National Institutes of Health
Openalex Percentile: Top 52%
Birth, Development, and Health
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Generalisability of Maternal Genetic Risk Score for Birth Weight Across Racial Identity and Ancestry: A Secondary Analysis of a Prospective Cohort Study — Jon G. Steller, Maryam Zeinomar, et al. · BJOG An International Journal of Obstetrics & Gynaecology (2025) | TGRS Research Map | TGRS