Pulmonary comorbidities and response to surfactant in late preterm infants: a multicenter cohort study
Surfactant therapy improves oxygenation in late preterm infants, but comorbidities such as PPHN and air leaks significantly reduce its effectiveness. Early administration is associated with a better response; treatment delays may contribute to poorer outcomes. Suboptimal response should prompt investigation for underlying conditions. Surfactant use should not be withheld solely based on gestational age.
Authors
- Renata Bokiniec (ORCID: https://orcid.org/0000-0002-1164-8406)
- Jan L Mazela (ORCID: https://orcid.org/0000-0001-9845-6759)
- Iwona Sadowska-Krawczenko (ORCID: https://orcid.org/0000-0001-8790-5176)
- Katarzyna Wróblewska‐Seniuk (ORCID: https://orcid.org/0000-0003-3908-6617)
- Mateusz Jagła (ORCID: https://orcid.org/0000-0002-7030-3934)
- Piotr Kruczek (ORCID: https://orcid.org/0000-0001-7596-1533)
- Roman Hożejowski (ORCID: https://orcid.org/0000-0002-1261-4670)
- Tomasz Szczapa (ORCID: https://orcid.org/0000-0002-5214-2719)
- Katarzyna Bierła
Institutions
- Poznan University of Medical Sciences (PL)
- Jagiellonian University (PL)
- Medical University of Warsaw (PL)
- Nicolaus Copernicus University (PL)
- Cracow University of Technology (PL)
- University of Bydgoszcz (PL)
- Lubawa (Poland) (PL)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1038/s41390-025-04634-5
- Citations
- 1
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Chiesi Farmaceutici
- Warszawski Uniwersytet Medyczny
- Uniwersytet Warszawski