Diverging conclusions from risk difference and difference in restricted mean survival time in quantifying absolute treatment effect heterogeneity
The pattern of HTE characterized by the RD may diverge substantially from the ΔRMST, potentially leading to treatment mistargeting. Therefore, we recommend the ΔRMST for assessing the absolute HTE in time-to-event data.
Authors
- David van Klaveren (ORCID: https://orcid.org/0000-0002-2096-606X)
- David M. Kent (ORCID: https://orcid.org/0000-0002-9205-5070)
- Carolien C. H. M. Maas (ORCID: https://orcid.org/0000-0002-3867-2465)
- Avinash G. Dinmohamed (ORCID: https://orcid.org/0000-0002-4767-6716)
Institutions
- Erasmus MC (NL)
- Netherlands Comprehensive Cancer Organisation (NL)
- Predictive Science (United States) (US)
Publication Details
- Journal
- International Journal of Epidemiology
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1093/ije/dyaf191
- Primary Topic
- Advanced Causal Inference Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00