Association of onset age with features of patients with systemic sclerosis in the Renji Scleroderma Longitudinal Cohort (Renji-SLOC)
Non-standard onset age predicts distinct organ-specific risks in SSc. Early-onset patients require prioritizing of cutaneous and pulmonary monitoring, while late-onset patients require vigilance for cardiopulmonary and gastrointestinal complications. Proteomic signatures mechanistically underlie this phenotypic heterogeneity. Patients with non-standard onset age require enhanced surveillance for organ-specific manifestations.
Authors
- Yuankai Sun (ORCID: https://orcid.org/0009-0000-5765-9795)
- Hanlin Yin (ORCID: https://orcid.org/0000-0003-0706-3998)
- Chaoyu Gu (ORCID: https://orcid.org/0009-0004-1131-8441)
- Liangjing Lu (ORCID: https://orcid.org/0000-0001-9116-6038)
- Fenglin Wu (ORCID: https://orcid.org/0000-0001-8287-4585)
- Zhewen Ding (ORCID: https://orcid.org/0000-0002-2252-8135)
- Zhigang Zhao (ORCID: https://orcid.org/0000-0003-3147-8544)
- Chenhan Jia (ORCID: https://orcid.org/0009-0009-5487-9843)
- Qianqian Li (ORCID: https://orcid.org/0000-0002-7508-2130)
- Xinyu Li (ORCID: https://orcid.org/0000-0002-5908-6676)
- Xuesong Liu (ORCID: https://orcid.org/0000-0002-4683-8998)
- Yan Ma (ORCID: https://orcid.org/0000-0001-7464-8107)
- Wanyi Lin (ORCID: https://orcid.org/0009-0009-2992-1456)
Institutions
- Renji Hospital (CN)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1093/rheumatology/keaf634
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00