Cytochrome P450 1A1 influences obesity‐induced pulmonary hypertension
These findings implicate augmented estrogen production by adipose tissue and elevated pulmonary CYP1A1 expression in the pathogenesis of obesity-associated PH. CYP1A1 may represent a novel therapeutic target in obese PAH patients.
Authors
- Ruth Andrew (ORCID: https://orcid.org/0000-0002-6916-2994)
- Joshua P. Dignam (ORCID: https://orcid.org/0000-0003-1826-6336)
- Sébastien Bonnet (ORCID: https://orcid.org/0000-0001-5753-1900)
- Ayman Gebril
- Sandra Breuils‐Bonnet
- Natalie Z M Homer (ORCID: https://orcid.org/0000-0002-9262-2098)
- Gregor Aitchison
- Margaret R. MacLean (ORCID: https://orcid.org/0000-0001-8214-7759)
- Martin Wabitsch (ORCID: https://orcid.org/0000-0001-6795-8430)
- Chelbi Coyle
- Smriti Sharma (ORCID: https://orcid.org/0000-0003-4206-8815)
- Sofia Laforest
- Ioannis Stasinopoulos (ORCID: https://orcid.org/0009-0007-0450-909X)
Institutions
- Queen Mary University of London (GB)
- University of Strathclyde (GB)
- Lung Institute (US)
- Child, Adolescent and Family Mental Health (CA)
- William Harvey Research Institute (GB)
- The Queen's Medical Research Institute (GB)
- Medical University of Vienna (AT)
- University of Edinburgh (GB)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-11-30
- DOI
- https://doi.org/10.1111/bph.70244
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00