The impact of single-nucleotide variants of hepatitis B virus and antiviral on liver cancer in gray zone patients
CHB patients in the gray zone remain at risk for HCC owing to both wild-type and HCC-associated HBV SNVs, especially the latter, inducing mitochondrial and metabolic dysfunctions. Antiviral therapy reduces the risk of HCC development in these patients.
Authors
- Chien‐Wei Su (ORCID: https://orcid.org/0000-0003-3889-7004)
- Yu‐Wei Chiou
- Jaw‐Ching Wu (ORCID: https://orcid.org/0000-0001-9645-3044)
- Wen‐Chun Liu (ORCID: https://orcid.org/0000-0001-9048-6363)
- Wei Teng (ORCID: https://orcid.org/0000-0001-5663-1440)
- Chih-Po Hsu (ORCID: https://orcid.org/0000-0002-4737-2800)
- Ting‐Tsung Chang (ORCID: https://orcid.org/0000-0002-5073-2678)
- Jie Xu (ORCID: https://orcid.org/0000-0002-8320-218X)
- Yu-Chuan Chang (ORCID: https://orcid.org/0000-0002-0001-3624)
- Yu‐Cheng Chang (ORCID: https://orcid.org/0000-0002-9634-8380)
- Yuh‐Jin Liang (ORCID: https://orcid.org/0000-0003-3774-3329)
Institutions
- National Tainan Institute of Nursing (TW)
- National Yang Ming Chiao Tung University (TW)
- Taipei Veterans General Hospital (TW)
- Chang Gung Memorial Hospital (TW)
- National Cheng Kung University Hospital (TW)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s12929-025-01195-x
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Academia Sinica
- Shanghai Educational Development Foundation
- Ministry of Education, India
- Chang Gung Medical Foundation
- Taipei Veterans General Hospital
- National Science and Technology Council