Impacts of leukocyte telomere length on incidence and severity of age-related cataract: a cross-cohort analysis
Longer LTL is associated with a reduced risk and severity of ARC, suggesting shared biological pathways between telomere attrition and lens aging. This supports the lens as a unique window for studying systemic aging and LTL as an index of modifiable health behaviors influencing cataract development.
Authors
- Xingchen Geng
- Zhuoting Zhu (ORCID: https://orcid.org/0000-0002-9897-1192)
- Ting Su (ORCID: https://orcid.org/0000-0001-6292-1209)
- Zijing Du (ORCID: https://orcid.org/0000-0002-8676-8293)
- Qin‐Yi Li (ORCID: https://orcid.org/0000-0003-1388-7686)
- Ningni Jiang (ORCID: https://orcid.org/0000-0002-6851-8928)
- Honghua Yu (ORCID: https://orcid.org/0000-0002-0782-346X)
- Xiayin Zhang (ORCID: https://orcid.org/0000-0003-0250-0247)
- Jian Cao (ORCID: https://orcid.org/0000-0002-3629-742X)
- Yijun Hu (ORCID: https://orcid.org/0000-0002-6424-7905)
- Chongrong Shen (ORCID: https://orcid.org/0000-0001-7164-3888)
- Mingguang He (ORCID: https://orcid.org/0000-0002-6664-3442)
- Yuling Xu (ORCID: https://orcid.org/0000-0003-1550-4618)
- Ying Fang (ORCID: https://orcid.org/0000-0001-7515-837X)
- Xianqi Zheng
- Guanrong Wu
Institutions
- Hong Kong Polytechnic University (HK)
- Jinan University (CN)
- The University of Melbourne (AU)
- Singapore National Eye Center (SG)
- Centre for Eye Research Australia (AU)
- Singapore Eye Research Institute (SG)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
Publication Details
- Journal
- Eye and Vision
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s40662-025-00465-x
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Guangdong Provincial People's Hospital
- Basic and Applied Basic Research Foundation of Guangdong Province