Iodine(III) Promoted Umpolung Cyclization of Thio/Seleno‐Urea With Enaminones: Preparation of 2‐Amino‐5‐acyl‐thiazoles/Selenazoles via C─N Bond Cleavage
ABSTRACT A hypervalent iodine‐mediated one‐step general method for the preparation of 2‐amino‐5‐acyl‐thiazoles and selenazoles has been disclosed. The reactions progress via umpolung cyclization of thio/seleno‐urea with enaminones. Mechanistically, the reaction progresses via C─N bond cleavage of enaminones rather than C═C bond.
Authors
- Rajiv K. Srivastava (ORCID: https://orcid.org/0000-0003-0703-3019)
- Bal Krishna Mishra
- Deepak Kumar (ORCID: https://orcid.org/0000-0001-6298-3565)
- Bhoopendra Tiwari (ORCID: https://orcid.org/0000-0002-4187-3313)
Institutions
- Centre of Biomedical Research (IN)
- Banaras Hindu University (IN)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2025-11-30
- DOI
- https://doi.org/10.1002/ajoc.202500624
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00