Bulk RNA-seq deconvolution heterogeneity across paired pancreatic cancer human samples
Together, the findings suggest that more than one tumor sample may be needed for effective treatment planning. Any potential difference in observed expression values across the paired samples could be related to the different cell type proportions across the samples. The sample size was small, and each study used different sequencing technologies, so any interpretation should be confirmed with additional studies.
Authors
- Hugues Sicotte (ORCID: https://orcid.org/0000-0002-0304-8515)
- Samuel O. Antwi (ORCID: https://orcid.org/0000-0003-2372-9489)
- Rick J. Jansen (ORCID: https://orcid.org/0000-0001-5683-2584)
- Kari G. Rabe (ORCID: https://orcid.org/0000-0002-7313-1875)
- Sarah A. Munro
Institutions
- University of Minnesota (US)
- Jacksonville College (US)
- University of Minnesota Medical Center (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-11-30
- DOI
- https://doi.org/10.3389/fgene.2025.1662924
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00