Metabolic profiles associated with fat loss in Parkinson’s disease
PD-related fat loss was accompanied by a pattern of lower glycolytic activity and higher levels of lipid and amino acid metabolism-related metabolites, consistent with a potential shift in energy utilisation. These findings highlight metabolic pathways as potential targets for interventions to mitigate weight loss in PD.
Authors
- Hirohisa Watanabe (ORCID: https://orcid.org/0000-0001-8553-8536)
- Reiko Ohdake (ORCID: https://orcid.org/0000-0001-8282-9434)
- Atsuhiro Higashi (ORCID: https://orcid.org/0009-0008-7408-9710)
- Atsushi Suzuki (ORCID: https://orcid.org/0000-0003-0807-199X)
- Mizuki Ito (ORCID: https://orcid.org/0000-0003-4470-1004)
- Sayuri Shima (ORCID: https://orcid.org/0000-0003-1761-0123)
- Yusuke Seino (ORCID: https://orcid.org/0000-0002-9099-3493)
- Yasuhiro Maeda (ORCID: https://orcid.org/0000-0001-8327-5875)
- Junichiro Yoshimoto (ORCID: https://orcid.org/0000-0001-7995-0321)
- Yasuaki Mizutani (ORCID: https://orcid.org/0000-0002-5709-8526)
- Akihiro Ueda (ORCID: https://orcid.org/0000-0002-9636-3011)
Institutions
- Fujita Health University (JP)
- Kobe University (JP)
Publication Details
- Journal
- Journal of Neurology Neurosurgery & Psychiatry
- Published
- 2025-11-30
- DOI
- https://doi.org/10.1136/jnnp-2025-336929
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Japan Society for the Promotion of Science