Intraperitoneal translocation of gut microbiota induces NETosis and promotes endometriosis
Our findings define a gut-peritoneum axis in endometriosis, where gut-derived <i>Pseudomonas</i> triggers NETosis in peritoneal Neu_MME to promote disease, suggesting that targeting this bacterium or NETosis represents a viable therapeutic strategy.
Authors
- Shuangdi Li (ORCID: https://orcid.org/0000-0002-7524-5753)
- Hua Wen Li (ORCID: https://orcid.org/0000-0002-4126-354X)
- Jin‐Jiao Chen (ORCID: https://orcid.org/0009-0005-7164-9469)
- Mingfu Wu (ORCID: https://orcid.org/0000-0003-0661-3054)
- Binya Liu (ORCID: https://orcid.org/0000-0003-1193-4821)
- Huang Siyuan (ORCID: https://orcid.org/0009-0006-3333-1422)
- Xiaoqing Zhong (ORCID: https://orcid.org/0009-0003-9621-2461)
- Wenliang Zhang (ORCID: https://orcid.org/0000-0003-0454-6935)
- Ruixin Zhu (ORCID: https://orcid.org/0000-0002-5070-6453)
- Liwen Tao
- Huimin Shen (ORCID: https://orcid.org/0009-0006-9125-850X)
- Wei Wang (ORCID: https://orcid.org/0009-0004-4049-5279)
- Yang Yang (ORCID: https://orcid.org/0009-0000-4768-9595)
- Liangsheng Fan (ORCID: https://orcid.org/0009-0003-0741-3203)
- Yingmiao Pan (ORCID: https://orcid.org/0009-0008-6270-9038)
- Xiang‐Guang Wu (ORCID: https://orcid.org/0000-0001-8276-4810)
- Shuangshuang Guo (ORCID: https://orcid.org/0009-0008-2621-0491)
- Yu Wu (ORCID: https://orcid.org/0009-0005-7500-6444)
Institutions
- Guiyang Medical University (CN)
- Sun Yat-sen University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Zhuhai People's Hospital (CN)
- ShenZhen People’s Hospital (CN)
- Qingzhou City People's Hospital (CN)
- Zhongshan People's Hospital (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Shanghai First Maternity and Infant Hospital (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Gut
- Published
- 2025-11-30
- DOI
- https://doi.org/10.1136/gutjnl-2025-336185
- Citations
- 1
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.70