Phase Separation of <scp>PHLDB2</scp> Drives <scp>EMT</scp> and Tumor Progression in Triple‐Negative Breast Cancer
Our findings demonstrate that PHLDB2 promotes TNBC progression by mediating ECM remodeling and EMT activation through phase separation-driven signal organization. These results establish PHLDB2 as a novel phase separation-dependent oncogenic regulator and highlight its potential as a prognostic biomarker and therapeutic target in TNBC.
Authors
- Jiqing Hao
- Min Zhang (ORCID: https://orcid.org/0000-0001-7055-6790)
- Ting Chen (ORCID: https://orcid.org/0000-0003-0179-3586)
- Xingyuan Shi (ORCID: https://orcid.org/0000-0002-1985-9654)
- Chanjin Liang
Institutions
- Anhui Medical University (CN)
- Twelfth Guangzhou City People's Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-11-30
- DOI
- https://doi.org/10.1002/cam4.71308
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wu Jieping Medical Foundation