Hypoxia-preconditioned bone marrow mesenchymal stem cell-derived exosomes ameliorate knee osteoarthritis by promoting cartilage regeneration and alleviating pain in rats
Hypo-BMSCs-Exos can effectively alleviate cartilage degeneration and pain in KOA, thus offering a novel and promising cell-free therapeutic strategy for the intervention of KOA.
Authors
- Bin-Bin Zhang (ORCID: https://orcid.org/0000-0002-9711-6741)
- Chuan Lu
- Kewen Li (ORCID: https://orcid.org/0000-0001-7950-2537)
- Bin Dou
- Wenzuo Gu
Institutions
- Qinghai University (CN)
- Qinghai University Affiliated Hospital (CN)
Publication Details
- Journal
- Regenerative Therapy
- Published
- 2025-11-30
- DOI
- https://doi.org/10.1016/j.reth.2025.101049
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00