NCAPD2 promotes the progression of lung adenocarcinoma through an AKT/MDM2/E2F1 positive feedback loop
This study reveals a novel role of NCAPD2 in promoting LUAD progression through the AKT/MDM2/E2F1 positive feedback loop. These findings provide new insights into the molecular pathogenesis of LUAD and suggest NCAPD2 as a potential therapeutic target for improving patient outcomes.
Authors
- Tailin Guo
- Ying Lin (ORCID: https://orcid.org/0000-0002-1280-2102)
- Xin Ning (ORCID: https://orcid.org/0000-0002-1476-0989)
- Lin Fan (ORCID: https://orcid.org/0009-0002-5513-7867)
- Junmin Wei (ORCID: https://orcid.org/0000-0002-2791-5070)
- Yan Chen (ORCID: https://orcid.org/0000-0003-0864-1630)
- Hongru Li (ORCID: https://orcid.org/0000-0002-5422-2341)
- Xiaoqin Li (ORCID: https://orcid.org/0000-0003-3762-9817)
- Yusheng Chen (ORCID: https://orcid.org/0000-0001-5292-1301)
- Yun Wu
- Yu–Chen Lin
- Da Hye Hong
Institutions
- Fujian Medical University (CN)
- Fuzhou Pulmonary Hospital of Fujian (CN)
- Fujian Provincial Hospital (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- Cancer Biology & Therapy
- Published
- 2025-11-30
- DOI
- https://doi.org/10.1080/15384047.2025.2589678
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00