Synergistic effects of niacinamide and low <scp>pH</scp> on melanin synthesis, melanocyte function and hyperpigmentation: In vitro and clinical insights
Our series of in vitro and clinical studies revealed groundbreaking findings on the role of pH modulation in enhancing the efficacy of niacinamide for hyperpigmentation reduction. By elucidating the synergistic mechanisms involved, this research paves the way for developing more effective treatments aimed at achieving a brighter and more uniform complexion safely.
Authors
- Laurie Moulton
- Tomohiro Hakozaki (ORCID: https://orcid.org/0000-0001-8882-1863)
- Jiazhen Wang (ORCID: https://orcid.org/0000-0003-2362-2884)
- Wenzhu Zhao
- Gang Deng
- Timothy Laughlin
Institutions
- AMS (Singapore) (SG)
- Procter & Gamble (United States) (US)
Publication Details
- Journal
- International Journal of Cosmetic Science
- Published
- 2025-11-30
- DOI
- https://doi.org/10.1111/ics.70044
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 0.00