Locus coeruleus‐entorhinal cortex tract integrity is linked to plasma tau and glial fibrillary acidic protein
Standard DTI model metrics in the LC- EC tract are linked to elevated plasma p-tau and GFAP. A higher ODI in the voxels containing the LC-EC tract is related to elevated plasma p-tau. LC-EC integrity links to AD-related biomarkers show topographic specificity. Lower LC-EC integrity may be a key indicator of the earliest AD-related pathology.
Authors
- Heidi I.L. Jacobs (ORCID: https://orcid.org/0000-0001-7620-3822)
- Yuliya Patsyuk
- Oskar Hansson (ORCID: https://orcid.org/0000-0001-8467-7286)
- Elouise A. Koops (ORCID: https://orcid.org/0000-0002-4105-4254)
- Elise Beckers (ORCID: https://orcid.org/0000-0002-5523-1741)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Shorena Janelidze (ORCID: https://orcid.org/0000-0003-2869-8378)
- Maxime Van Egroo (ORCID: https://orcid.org/0000-0002-3142-2623)
- Benedikt Andreas Poser (ORCID: https://orcid.org/0000-0001-8190-4367)
- Nicholas J. Ashton
- Kaj Blennow
Institutions
- University of Wisconsin–Madison (US)
- Harvard University (US)
- University of Liège (BE)
- King's College London (GB)
- Lund University (SE)
- Stavanger University Hospital (NO)
- Maastricht University Medical Centre (NL)
- Sahlgrenska University Hospital (SE)
- Centre for Mental Health (GB)
- Maastricht University (NL)
- Massachusetts General Hospital (US)
- UK Dementia Research Institute (GB)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-11-30
- DOI
- https://doi.org/10.1002/alz.70915
- Citations
- 1
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Alzheimer's Association
- BrightFocus Foundation
- Familjen Erling-Perssons Stiftelse
- Cure Alzheimer's Fund
- Stiftelsen för Gamla Tjänarinnor
- EU Joint Programme – Neurodegenerative Disease Research
- Australian Government
- European Commission
- Hjärnfonden
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse
- University College London Hospitals NHS Foundation Trust
- Alzheimer Nederland
- Skånes universitetssjukhus
- Marcus och Amalia Wallenbergs minnesfond
- UK Dementia Research Institute
- National Institutes of Health
- Parkinsonfonden
- Horizon 2020 Framework Programme
- HORIZON EUROPE Framework Programme
- HORIZON EUROPE Marie Sklodowska-Curie Actions