Design Optimization for Developing Population Pharmacokinetic Models in Critically Ill Children: Application to Teicoplanin, Piperacillin and Meropenem
This work emphasizes the importance of optimizing study designs to improve accuracy and precision in the model parameters while reducing the number of samples needed. This is a relevant advantage especially when dealing with critically ill pediatric patients.
Authors
- Laura Butragueño Laiseca (ORCID: https://orcid.org/0000-0001-5430-0488)
- María José Santiago (ORCID: https://orcid.org/0000-0001-8149-1179)
- Zinnia P. Parra‐Guillén (ORCID: https://orcid.org/0000-0003-1503-2710)
- Iñaki F. Trocóniz (ORCID: https://orcid.org/0000-0003-3700-8658)
- Gastón García-Orueta
Institutions
- Instituto de Salud Carlos III (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Navarre Institute of Health Research (ES)
- Hospital Materno-Infantil (ES)
- Departamento de Salud (ES)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1007/s40262-025-01594-1
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00