Correlation between immune biomarkers and surrogate markers of severity of Acute Pancreatitis in an HIV endemic region
Distinct immune signatures correlate with AP severity and are significantly influenced by HIV status. IL-15 outperformed IL-6, TNF-α, IL-17, and MCP-1 in people without HIV, whereas TNF-α was the only predictor of severity in PLWH. Higher thresholds for prediction of severity in PLWH underscore the need for HIV-specific biomarker thresholds and further research into tailored severity stratification, and development of immunomodulating therapies in AP.
Authors
- Mette Kongstad
- K. Chiliza
- Kasmira Gopee
- Mustafa Ghanizada (ORCID: https://orcid.org/0000-0002-2774-2157)
- Fusi Madela (ORCID: https://orcid.org/0000-0002-5663-3160)
- Stéphane Ostrowski (ORCID: https://orcid.org/0000-0002-0875-120X)
- Colleen Aldous (ORCID: https://orcid.org/0000-0002-7199-9160)
- Henrik N. Kløverpris (ORCID: https://orcid.org/0000-0002-2165-3313)
- S R Thomson (ORCID: https://orcid.org/0000-0002-9485-997X)
- María José Marín (ORCID: https://orcid.org/0000-0003-0206-4756)
- X Mfeka
Institutions
- University of Copenhagen (DK)
- University of Cape Town (ZA)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Africa Health Research Institute (ZA)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- Pancreatology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1016/j.pan.2025.11.014
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00