Associations between patient-reported neurocognition, mood, and fatigue and radiation dose in oropharyngeal cancer survivors
There are potential positive associations between right-posterior cerebellum dose with late mood disturbance and fatigue, including potential dose-effect thresholds and cerebella sensitivity to dose per fraction. Further research is needed to clarify these findings, and to establish causality.
Authors
- Eliana Vásquez Osorio (ORCID: https://orcid.org/0000-0003-0741-994X)
- J. Lilley (ORCID: https://orcid.org/0000-0003-0060-0316)
- Zsuzsanna Iyizoba-Ebozue (ORCID: https://orcid.org/0000-0002-9839-4532)
- Emma Nicklin (ORCID: https://orcid.org/0000-0002-6683-8098)
- Marcus Tyyger (ORCID: https://orcid.org/0000-0001-8491-1298)
- Florien Willemijn Boele (ORCID: https://orcid.org/0000-0003-0409-7949)
- Louise Murray (ORCID: https://orcid.org/0000-0003-0658-6455)
Institutions
- University of Leeds (GB)
- University of Manchester (GB)
- Cancer Research UK Manchester Institute (GB)
- NHS Digital (GB)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1016/j.radonc.2025.111309
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00