History of glucagon-like peptide-1 receptor agonists
• GLP-1RA development traces a century of translational progress from gut hormones to multi-agonist therapeutics. • Rational protein engineering and delivery innovations transformed incretin biology into global metabolic therapeutics. • Modern dual and triple agonists achieve surgical-level metabolic benefits, redefining diabetes and obesity care.
Authors
- Alexandra E. Butler (ORCID: https://orcid.org/0000-0002-5762-3917)
- Radwan Darwish (ORCID: https://orcid.org/0009-0009-3419-4118)
- Ghena Abu-Sharia
Institutions
- Alfaisal University (SA)
- Royal College of Surgeons in Ireland - Bahrain (BH)
Publication Details
- Journal
- Pharmacological Research
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1016/j.phrs.2025.108045
- Citations
- 3
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 3.88