Longitudinal proteomic and autoantibody signatures after mRNA vaccination in healthy individuals
Integrated plasma proteomics and autoantibody profiling demonstrated sustained immunogenicity and safety of SARS-CoV-2 mRNA vaccines, characterized by durable spike-specific antibody responses, late-onset complement activation, and limited autoantibody induction. These findings enhance our understanding of vaccine-induced immunity and inform long-term monitoring and optimization of mRNA vaccine strategies.
Authors
- L E Becker (ORCID: https://orcid.org/0000-0003-4506-0878)
- Jennifer E. Van Eyk (ORCID: https://orcid.org/0000-0001-9050-148X)
- Aleksandra Binek (ORCID: https://orcid.org/0000-0001-5764-7137)
- Blandine Chazarin (ORCID: https://orcid.org/0009-0004-4488-4298)
- Jana Gajewski
- Niveda Sundararaman (ORCID: https://orcid.org/0000-0001-7708-3754)
- Koen Raedschelders (ORCID: https://orcid.org/0000-0003-0835-4762)
- Hans-Dieter Zucht
- Petra Budde (ORCID: https://orcid.org/0000-0001-8991-3495)
- Justyna Fert‐Bober (ORCID: https://orcid.org/0000-0002-2824-5056)
- Sandy Joung (ORCID: https://orcid.org/0000-0002-7582-3218)
- Kimia Sobhani (ORCID: https://orcid.org/0000-0002-9297-3445)
- Rowann Mostafa
- Brian Walker (ORCID: https://orcid.org/0000-0001-7345-2110)
- Archana Bhat (ORCID: https://orcid.org/0000-0002-7484-4842)
- Joseph E. Ebinger (ORCID: https://orcid.org/0000-0002-0587-1572)
- Yunxian Liu (ORCID: https://orcid.org/0000-0002-3570-103X)
- Ann-Sophie Lindemann
Institutions
- Cedars-Sinai Medical Center (US)
- Cedars-Sinai Smidt Heart Institute (US)
Publication Details
- Journal
- Vaccine
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1016/j.vaccine.2025.127888
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cedars-Sinai Medical Center
- National Institutes of Health
- National Cancer Institute