Exploring effects of chronic <scp>d</scp> ‐cycloserine administration on expression of GluN2 subunits and tripartite synaptic transmission in thalamocortical pathway
Chronic d-cycloserine (25 μM and 2 mg·kg<sup>-1</sup>) down-regulated GluN2C without affecting GluN2A/GluN2B but increased GluN2-related astroglial l-glutamate/d-serine release. Higher d-cycloserine dose (>60 μM; >5 mg·kg<sup>-1</sup>) inactivated GluN2C, but increased GluN2A related astroglial release. These results indicate that dose-dependent activation and inactivation of GluN2C by d-cycloserine is possibly involved in its efficacy on negative symptom of schizophrenia, but with a narrow therapeutic window.
Authors
- Motohiro Okada (ORCID: https://orcid.org/0000-0002-9025-2548)
- Eishi Motomura (ORCID: https://orcid.org/0000-0003-3013-9284)
- Nobutomo Yamamoto (ORCID: https://orcid.org/0000-0001-7979-8243)
- Ruri Okubo (ORCID: https://orcid.org/0009-0009-9842-8702)
Institutions
- Mie University (JP)
- National Mie Hospital (JP)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1111/bph.70262
- Primary Topic
- Amino Acid Enzymes and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science