Relationship Between the Systemic Immune‐Inflammation Index and Non‐Dipper Blood Pressure Status in Normotensive Patients With Prediabetes

Prediabetes is the period in which serum glucose levels begin to rise but do not yet meet the criteria for diabetes. Non-dipper blood pressure (BP) is related to a significant increase in cardiovascular disease (CVD) and organ damage compared to those with dipper BP in hypertensive individuals. Inflammation plays a role in the development of atherosclerosis and CVD. The data on whether nighttime status is important in normotensive individuals are limited. We aimed to investigate the relationship between dipper and non-dipper BP status and inflammatory parameters in normotensive patients with prediabetes. The study had a cross-sectional design. Of the 208 prediabetic and normotensive individuals included in the study, 90 were in the dipper BP group, and 118 were in the non-dipper BP group. In all subjects, the collection of venous peripheral blood samples was performed on admission. The two groups exhibited similar clinical baseline characteristics. C-reactive protein (CRP) and systemic immune-inflammation index (SII) were significantly higher in the non-dipper BP group (CRP: 7.19 ± 4.01 vs. 6.20 ± 4.32 mg/L, p = 0.043; SII: 782.79 vs. 613.43, p = 0.014). In the logistic regression analysis, SII was independently associated with non-dipper BP status [OR = 1.001, CI (1.000-1.001), p = 0.017]. In prediabetic patients, non-dipper BP status may be associated with inflammation and, consequently, increased CVD risk, even in normotensive individuals. Identifying factors that increase the risk in prediabetic patients may be important in terms of improving their future cardiovascular health.