Longitudinal Associations of Serum Orexin‐A With Physical Activity and Sleep in Schizophrenia: A Preliminary Study
In this preliminary longitudinal sample, increases in serum OXA were linked to greater daytime activity and reduced time in bed, suggesting that orexinergic signaling may modulate behavioral regulation in schizophrenia beyond its established role in sleep-wake control. Larger studies, with adjustment for multiple comparisons, are warranted to evaluate OXA as a candidate biomarker or therapeutic target.
Authors
- Konatsu Saito
- Shinsuke Washizuka
- Kazuhiro Suzuki (ORCID: https://orcid.org/0000-0002-0038-4329)
- Daimei Sasayama (ORCID: https://orcid.org/0000-0003-3450-7283)
- Shinsuke Yoshida (ORCID: https://orcid.org/0000-0003-0659-9352)
- Yusuke Arai (ORCID: https://orcid.org/0000-0002-3155-6971)
- Toshinori Nakamura (ORCID: https://orcid.org/0000-0001-8129-4220)
- Yuka Nakajima (ORCID: https://orcid.org/0000-0002-7357-2910)
- Akira Tanaka (ORCID: https://orcid.org/0000-0002-2623-8151)
- Takehiko Yasaki
- Mika Koido
- Erika Nakashizuka
Institutions
- Shinshu University (JP)
- Nagano Municipal Hospital (JP)
- Nagano Red Cross Hospital (JP)
- Japanese Red Cross Narita Hospital (JP)
Publication Details
- Journal
- Neuropsychopharmacology Reports
- Published
- 2025-11-30
- DOI
- https://doi.org/10.1002/npr2.70079
- Citations
- 1
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 1.43