A Phase 1 Double-Blinded Trial to Evaluate Safety, Immunogenicity, and Dosing of Measles-Vectored Chikungunya Virus Vaccine (MV-CHIK) in Healthy Adults
This study of a measles-vectored vaccine for chikungunya virus (MV-CHIK) was a Phase 1 randomized, double-blinded, placebo-controlled trial with varying intervals between the 2 doses. The 6 cohorts each had 30 subjects, of which 25 received MV-CHIK and 5 received placebo. The 5 × 105 TCID50 dose was superior to the 5 × 104 TCID50 dose, and longer dosing intervals resulted in higher titers in the high dose groups. Mild to moderate injection site and systemic reactogenicity was common but brief. There was no evidence of prolonged vaccine-related arthralgia.
Authors
- Theresa Hegmann (ORCID: https://orcid.org/0000-0002-6985-7964)
- Venus Shahamatdar
- Robert L. Atmar (ORCID: https://orcid.org/0000-0001-9989-6772)
- Hana M. El Sahly (ORCID: https://orcid.org/0000-0003-0489-0074)
- İnci Yıldırım (ORCID: https://orcid.org/0000-0002-8631-0020)
- Carol Kao
- Patricia L. Winokur (ORCID: https://orcid.org/0000-0002-4826-1790)
- Walla Dempsey
- Etza Peters
- Christina A. Rostad (ORCID: https://orcid.org/0000-0001-8439-0592)
- Kay M. Tomashek (ORCID: https://orcid.org/0000-0001-7741-7072)
- Evan J. Anderson (ORCID: https://orcid.org/0000-0002-1576-4420)
- Jumi Yi
- Nancy B. Wagner
- Thomas M. Kaufman
- Kathy Stephens
- Wendy A. Keitel
- Tatiana Beresney
Institutions
- University of Iowa (US)
- Emory University (US)
- Baylor College of Medicine (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-11-15
- DOI
- https://doi.org/10.1093/infdis/jiaf571
- Primary Topic
- Virology and Viral Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00