Novel MAFG-METTL14-SCD1 axis regulates lipid metabolism mediating choroidal melanoma distant metastasis
Our study identifies SCD1-mediated lipid remodeling as a key driver of enhanced membrane fluidity and metastatic potential in CM. Inhibition of SCD1 increases lipid saturation, reduces membrane fluidity, induces oxidative stress, and suppresses liver and lung metastasis. The MAFG-METTL14-SCD1 axis thus represents a critical regulator of CM progression, and combined therapeutic targeting with aramchol and S-HFD offers promising translational potential.
Authors
- Minjie Wei (ORCID: https://orcid.org/0000-0001-5548-7280)
- Hong Ning (ORCID: https://orcid.org/0000-0002-8316-7521)
- Xue Bai (ORCID: https://orcid.org/0000-0002-5203-4080)
- Xiao Hu (ORCID: https://orcid.org/0000-0003-1128-4099)
- Jiling Ru
- Yuan Peng (ORCID: https://orcid.org/0000-0001-9563-9568)
- Xianjie Liu (ORCID: https://orcid.org/0000-0002-3190-2774)
- Z. Zhang (ORCID: https://orcid.org/0000-0003-2766-5902)
- Huizhe Wu (ORCID: https://orcid.org/0000-0001-7964-1342)
- Xianglong Zhu (ORCID: https://orcid.org/0000-0003-4700-5688)
- Jun Li (ORCID: https://orcid.org/0000-0001-7541-752X)
- Xi Zhang (ORCID: https://orcid.org/0000-0002-0422-8980)
- Xiaonan Zhang (ORCID: https://orcid.org/0000-0002-1286-7280)
- Li Han (ORCID: https://orcid.org/0000-0002-3654-171X)
- Yingqi Zhao (ORCID: https://orcid.org/0009-0006-1972-2662)
- Chen Fu (ORCID: https://orcid.org/0000-0002-2343-1802)
- Yan Yang (ORCID: https://orcid.org/0009-0008-0237-9188)
Institutions
- Fourth Affiliated Hospital of China Medical University (CN)
- First Hospital of China Medical University (CN)
- Liaoning Cancer Hospital & Institute (CN)
- China Medical University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s13046-025-03595-1
- Citations
- 1
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94