Contemporary Highly Pathogenic Avian Influenza (H5N1) Viruses Retain Neurotropism in Human Cerebral Organoids
Clade 2.3.4.4b HPAI H5N1 viruses exhibit similar neurotropism compared to a historical clade 1 HPAI H5N1 virus. Lower levels of cell death and inflammatory cytokine production induced by clade 2.3.4.4b viruses may indicate reduced neuropathogenic potential of these viruses in humans.
Authors
- Kerry Goldin (ORCID: https://orcid.org/0000-0001-5448-4088)
- Cathryn L. Haigh (ORCID: https://orcid.org/0000-0001-7591-1149)
- Meaghan Flagg (ORCID: https://orcid.org/0000-0003-2173-2860)
- Emmie de Wit (ORCID: https://orcid.org/0000-0002-9763-7758)
- Tessa Lutterman
- Katie Williams (ORCID: https://orcid.org/0000-0002-7400-6056)
- Bridget Brackney
Institutions
- National Institutes of Health (US)
- National Institute of Allergy and Infectious Diseases (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1093/ofid/ofaf730
- Primary Topic
- Infectious Encephalopathies and Encephalitis
- Type
- article
- Field-Weighted Citation Impact
- 0.00