Cumulative incidence and risk factors for advanced neoplasia following inflammatory bowel disease-related low-grade dysplasia: a Danish nationwide cohort study
Among Danish individuals with IBD-related LGD, the overall 15-year cumulative incidence of subsequent HGD or CRC was 6.3% and has declined markedly over time. In addition to established risk factors, including age, IBD duration, family history of CRC, and elevated fecal calprotectin, we found that high-dose prednisone use was associated with an increased risk.
Authors
- Klaus Krogh (ORCID: https://orcid.org/0000-0001-9168-2403)
- Frederikke Schønfeldt Troelsen (ORCID: https://orcid.org/0000-0002-5276-5959)
- Ailsa Hart
- J Andersen (ORCID: https://orcid.org/0000-0003-2140-5464)
- Anders Dige (ORCID: https://orcid.org/0000-0001-9995-0329)
- David Haldrup (ORCID: https://orcid.org/0000-0003-0023-8564)
Institutions
- Aarhus University (DK)
- Aarhus University Hospital (DK)
- St. Mark's Hospital (US)
- Regional Hospital Randers (DK)
- St Mark's Hospital (GB)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1093/ecco-jcc/jjaf219
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.82