Tissue expression of miR-504-5p and miR-429 as diagnostic biomarkers for endometrial cancer and endometrial intraepithelial neoplasia: a pilot study

Our preliminary findings suggest that reduced expression of miR-504-5p and miR-429 characterizes the transition from EIN to EC, supporting their potential role as tumor suppressors in this setting. This two-miRNA panel could complement histopathology in distinguishing precursor lesions from carcinoma, addressing a key diagnostic challenge. Larger studies, including minimally invasive liquid biopsy approaches, are warranted to validate their clinical utility.