Piperlongumine Induces Apoptosis and Autophagy <i>via</i> the MAPK/NK-κB Pathway in Human Breast Cancer Cells

In SK-BR-3 and T47D breast cancer cell lines, piperlongumine induces apoptosis <i>via</i> the MAPK/NF-κB pathway and promotes autophagy. These findings suggests that piperlongumine may serve as a potential therapeutic agent against human breast cancer cells.

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Publication Details

Journal
Anticancer Research
Published
2025-11-29
DOI
https://doi.org/10.21873/anticanres.17878
Primary Topic
Piperaceae Chemical and Biological Studies
Type
article
Field-Weighted Citation Impact
0.00
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Piperlongumine Induces Apoptosis and Autophagy via the MAPK/NK-κB Pathway in Human Breast Cancer Cells

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Piperlongumine Induces Apoptosis and Autophagy via the MAPK/NK-κB Pathway in Human Breast Cancer Cells

Byeong-Soo Kim, Yun Seo Jang, Ji‐Youn Jung, Ho Hee Jang, Sua Lee, Myeon‐Sik Yang, Sang‐Ki Kim, Soo‐Hyun Jung, Y. Park, SU-JI JEON, SANG-WOO LEE, BYUNG-KWON PARK
article en

Abstract

In SK-BR-3 and T47D breast cancer cell lines, piperlongumine induces apoptosis <i>via</i> the MAPK/NF-κB pathway and promotes autophagy. These findings suggests that piperlongumine may serve as a potential therapeutic agent against human breast cancer cells.

Anticancer ResearchVol. 45(12)
Kongju National University (KR)
Openalex Percentile: Top 54%
Piperaceae Chemical and Biological Studies
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