Rapid Eradication of Extensive Spinal Metastases in a Prostate-Cancer Patient Taking Androgen-deprivation Therapy, Chemotherapy, and Oral Recombinant Methioninase on a Low-Methionine Diet
The patient achieved an apparent complete response of prostate-cancer spinal metastases after treatment with ADT, chemotherapy, and methionine restriction. Further studies, including controlled clinical trials are necessary to validate this new paradigm of treatment for prostate-cancer bone metastases.
Authors
- Shinji Miwa (ORCID: https://orcid.org/0000-0002-5962-8287)
- SHUKUAN LI
- Hiroaki Kimura (ORCID: https://orcid.org/0000-0002-7441-0382)
- Hiroyuki Tsuchiya
- Byung Mo Kang (ORCID: https://orcid.org/0000-0003-0900-094X)
- Yohei Asano (ORCID: https://orcid.org/0000-0002-8777-6076)
- Katsuhiro Hayashi (ORCID: https://orcid.org/0000-0001-8665-2154)
- Robert M. Hoffman (ORCID: https://orcid.org/0000-0002-0049-0041)
- Takashi Higuchi (ORCID: https://orcid.org/0000-0003-2896-4939)
- Satoru Demura
- Norio Yamamoto (ORCID: https://orcid.org/0000-0001-8924-0710)
- TOSHIHIKO SATO
- CHIHIRO HOZUMI
- Kentaro Igarashi (ORCID: https://orcid.org/0000-0003-2278-1736)
- Sei Morinaga (ORCID: https://orcid.org/0000-0003-2961-9432)
- Jin-Soo Kim (ORCID: https://orcid.org/0000-0002-1847-3741)
- Qinghong Han
- YUTA MIYASHI
Institutions
- Kanazawa University (JP)
- University of California San Diego (US)
- AntiCancer (United States) (US)
- Japanese Red Cross Narita Hospital (JP)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-11-29
- DOI
- https://doi.org/10.21873/anticanres.17912
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00