Bis-type Triaziquone Induces PARP1-mediated Cell Death in Human NPC/HK1 Nasopharyngeal Carcinoma Cells
BTZQ selectively inhibits NPC cell viability by inducing PARP1-mediated cell death rather than apoptosis. These findings identify BTZQ as a promising candidate for NPC therapy and suggest that targeting PARP1-mediated cell death may represent a novel therapeutic strategy for this malignancy.
Authors
- Yingxiao Li
- Chih-Chun Wang (ORCID: https://orcid.org/0000-0002-1685-820X)
- Yu-Yan Lan (ORCID: https://orcid.org/0000-0003-4436-2057)
- Meng-Che Hsieh
- Tsair Kao
- Tzer-Zen Hwang
Institutions
- E-Da Hospital (TW)
- I-Shou University (TW)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-11-29
- DOI
- https://doi.org/10.21873/anticanres.17881
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00