Potential Role of Tumor-derived <i>MIF</i> in B-Cell Antigen Presentation in Lung Adenocarcinoma: Single-cell and TCGA Analyses
Tumor-derived <i>MIF</i> is associated with poor prognosis, likely by suppressing the immune system, but it also promotes the induction of APC-like B cells, which are associated with improved outcomes, highlighting its dual role in LUAD. These findings position <i>MIF</i> as a potential therapeutic target and suggest that MIFR<sup>+</sup> B cells could serve as important prognostic markers.
Authors
- Sarah Khan (ORCID: https://orcid.org/0000-0001-5608-8070)
- Fadwa Ahmed (ORCID: https://orcid.org/0000-0003-0128-0502)
Institutions
- Copenhagen University Hospital (DK)
- University of Jeddah (SA)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-11-29
- DOI
- https://doi.org/10.21873/anticanres.17874
- Citations
- 1
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 0.80