Inhibition of Cholesterol Transport from Lysosomes by Itraconazole Repolarizes Tumor-associated Macrophages to Anti-tumor M1 type
Inhibition of lysosomal cholesterol release by ITZ reprogrammed M2 macrophages into an M1-like phenotype, revealing a novel mechanism that may serve as a foundation for developing innovative TAM-targeted immunotherapies.
Authors
- YU WAKIMOTO
- Sachiyo Narita
- Roze Taniguchi
- Kazuko Sakata (ORCID: https://orcid.org/0000-0001-6509-216X)
- Yoshiharu Tsubamoto
- Hiroshi Tsubamoto (ORCID: https://orcid.org/0000-0002-6135-6313)
- Seiji Mabuchi (ORCID: https://orcid.org/0000-0003-1803-1166)
- Tomoko Ueda
- Atsushi Tamura
- Yumi Takimoto (ORCID: https://orcid.org/0000-0002-2587-1502)
Institutions
- Tokyo Medical and Dental University (JP)
- Hyogo Medical University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-11-29
- DOI
- https://doi.org/10.21873/anticanres.17866
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00