<i>NSUN7</i> Suppression Reduces Metastatic Potential and Restores Sensitivity to 4-OH Tamoxifen in Resistant MCF-7 Cells
Our study identified that <i>NSUN7</i> regulates key oncogenic pathways associated with tamoxifen resistance and metastasis. Its suppression enhanced tamoxifen sensitivity and reduced metastatic potential, collectively highlighting <i>NSUN7</i> as a novel driver of tamoxifen resistance and a potent therapeutic target in estrogen receptor-positive breast cancer.
Authors
- Andrei V. Chernov (ORCID: https://orcid.org/0000-0002-3294-5418)
- Hemal H. Patel (ORCID: https://orcid.org/0000-0001-6722-9625)
- Sana Mahmood
- Shawana Z Khan
- S. A. Qureshi (ORCID: https://orcid.org/0009-0007-5105-0066)
- Chitteti Ramamurthy (ORCID: https://orcid.org/0000-0002-5202-8481)
- Asma Gul (ORCID: https://orcid.org/0000-0003-0338-3134)
- SALMMA SALAMAH SALIHAH
Institutions
- International Islamic University, Islamabad (PK)
- Shalamar Hospital (PK)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-11-29
- DOI
- https://doi.org/10.21873/anticanres.17871
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00