Leveraging Genome-wide Association Studies to Identify Pathogenic Variants for Breast Cancer Among Multiple Continents
This integrative bioinformatics approach prioritized functionally significant BCa-associated SNPs and identified promising candidates for biomarker development and drug repositioning. The nine high-scoring variants, including <i>SLCO1B1</i> and <i>ARHGEF38</i> emerge as biologically impactful genes, while MAPT's known drug interactions highlight its translational potential in repurposing existing anticancer agents.
Authors
- Lalu Muhammad Irham (ORCID: https://orcid.org/0000-0002-0091-4887)
- Rockie Chong
- Wirawan Adikusuma (ORCID: https://orcid.org/0000-0001-9165-690X)
- Benni Iskandar (ORCID: https://orcid.org/0000-0002-5635-8357)
- İlker Ateş (ORCID: https://orcid.org/0000-0001-5791-7694)
- Danang Prasetyaning Amukti (ORCID: https://orcid.org/0000-0002-4256-6534)
- Darmawi Darmawi (ORCID: https://orcid.org/0000-0002-5579-1749)
- Desie Rahmawati
- Brilliant Citra Wirashada
- Putri Permata Suka Admanegara
- Baik Heni Rispawati
- Rista Yulianti
- Siska Widiastuti
Institutions
- Yogyakarta State University (ID)
- Ankara University (TR)
- University of California, Los Angeles (US)
- University of Mataram (ID)
- Universitas Ahmad Dahlan (ID)
- National Research, Development and Innovation Office (HU)
- Universitas Muhammadiyah Riau (ID)
- Universitas Muhammadiyah Surabaya (ID)
- Silpakorn University (TH)
- Riau University (ID)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-11-29
- DOI
- https://doi.org/10.21873/anticanres.17873
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Direktorat Riset dan Pengabdian Masyarakat
- Direcció General de Recerca, Generalitat de Catalunya