Homochlorcyclizine Dihydrochloride Inhibits Hepatocellular Carcinoma Progression and Cancer Stem Cell Properties
Homochlorcyclizine dihydrochloride exerts potent anti-HCC activity by suppressing proliferation, migration, and CSC characteristics, likely mediated by down-regulation of CDC20 and CDK1. Its established safety profile positions homochlorcyclizine dihydrochloride as a compelling candidate for repurposing as a novel HCC therapy, warranting further clinical exploration.
Authors
- Weijun Su (ORCID: https://orcid.org/0000-0002-2836-5445)
- Xiaobing Fu (ORCID: https://orcid.org/0000-0002-2465-1700)
- S. Y. Chang
- Jiayi Wu (ORCID: https://orcid.org/0009-0001-9291-0399)
Institutions
- Nankai University (CN)
- Zhengzhou University (CN)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-11-29
- DOI
- https://doi.org/10.21873/anticanres.17882
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 0.00