Dapagliflozin enhances hemodynamic and metabolic recovery following cardioplegic arrest in the isolated working mouse heart
Our findings underscore the potential of SGLT2i to improve hemodynamic recovery following cardioplegic arrest, supporting further exploration of dapagliflozin as novel myocardial protective regimen in cardiac surgery.
Authors
- Chiara Riganti (ORCID: https://orcid.org/0000-0001-9787-4836)
- Attila Kiss (ORCID: https://orcid.org/0000-0003-4652-1998)
- Seth Hallström (ORCID: https://orcid.org/0000-0002-3160-7388)
- Martina Godel (ORCID: https://orcid.org/0000-0002-2573-126X)
- Patrick M. Pilz (ORCID: https://orcid.org/0000-0001-6149-8736)
- Alessandra Ghigo (ORCID: https://orcid.org/0000-0002-1193-5296)
- Barbara Kapeller
- Ana Isabel Antunes Goncalves (ORCID: https://orcid.org/0009-0009-3428-3321)
- Christopher Dostal (ORCID: https://orcid.org/0000-0003-4961-6458)
- Bruno Karl Podesser (ORCID: https://orcid.org/0000-0002-4641-7202)
- Julius Reiner (ORCID: https://orcid.org/0009-0009-6410-8858)
- Lukas M. Weber (ORCID: https://orcid.org/0000-0002-3282-1730)
- Daniel Camillo Spona (ORCID: https://orcid.org/0009-0000-2379-6732)
- Laurenz Wolner (ORCID: https://orcid.org/0009-0005-4266-9321)
- Giulia Guerra (ORCID: https://orcid.org/0000-0002-9685-0530)
- Gülsüm Yılmaz (ORCID: https://orcid.org/0000-0003-2612-6173)
- Anna Stampfer
Institutions
- Ludwig Boltzmann Institute for Cardiovascular Research (AT)
- Ludwig Boltzmann Institute Applied Diagnostics (AT)
- Ludwig Boltzmann Institute for Cancer Research (AT)
- University of Turin (IT)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1016/j.biopha.2025.118771
- Citations
- 1
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 1.47