Synthesis and Application of Chitosan‐Salicylic Acid Magnetic Nanoparticles in Colon Cancer Cells
ABSTRACT In this study, magnetic nanoparticles (Fe 3 O 4 @CS‐SAL) were synthesized using chitosan as a stabilizer and conjugated with salicylic acid. The nanoparticles were characterized by powder x‐ray diffraction (PXRD), field emission electron microscopy (FESEM), and transmission electron microscopy (TEM). PXRD analysis determined a grain size of approximately 19 nm, while FESEM and TEM confirmed their spherical morphology with a mean diameter of ∼100 nm and a narrow size distribution. The cytotoxicity of Fe 3 O 4 @CS‐SAL was evaluated against colon cancer cells (C26), demonstrating significant toxic effects. Additionally, their antioxidant activity was assessed via the DPPH assay, yielding an IC 50 of approximately 62.5 µg/mL.
Authors
- Sarah Mousavi (ORCID: https://orcid.org/0000-0001-9792-1428)
- Ignacio M. López‐Coca (ORCID: https://orcid.org/0000-0001-9120-4495)
- Mohammad Mashreghi (ORCID: https://orcid.org/0000-0002-5197-6260)
- Mohsen Mohammadi (ORCID: https://orcid.org/0000-0002-1580-6539)
- Mohammad Qandalee (ORCID: https://orcid.org/0000-0002-3404-8577)
- Abbas Ebadi (ORCID: https://orcid.org/0000-0002-2911-7005)
- Mohammad Ehsan Taghavizadeh Yazdi (ORCID: https://orcid.org/0000-0003-0086-8005)
- Hossein Behmadi
- Ali Es‐haghi (ORCID: https://orcid.org/0000-0001-5292-6161)
- Carlos Javier Duran-Valle (ORCID: https://orcid.org/0000-0002-2507-4650)
- Mohammad Ebadi (ORCID: https://orcid.org/0000-0001-5326-493X)
Institutions
- Islamic Azad University of Garmsar (IR)
- Mashhad University of Medical Sciences (IR)
- Islamic Azad University, Mashhad (IR)
- Universidad de Extremadura (ES)
Publication Details
- Journal
- Nano Select
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1002/nano.70086
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00