Genetics of PLCG2 expression and splicing relative to Alzheimer’s disease risk
We report that two AD genetic risk factors, rs12446759 and rs1071644, affect AD risk by impacting the <i>LNC-PLCG2</i> to <i>PLCG2</i> ratio and <i>PLCG2</i> exon 28 splicing, respectively.
Authors
- Kathy Dotson
- Steven Estus (ORCID: https://orcid.org/0000-0001-6900-6003)
- Kelvin Cain (ORCID: https://orcid.org/0000-0001-7910-6075)
- A. Turner (ORCID: https://orcid.org/0000-0001-5559-6559)
- David W. Fardo (ORCID: https://orcid.org/0000-0002-7207-4696)
- James F. Simpson
- Qi Qiao (ORCID: https://orcid.org/0000-0002-0112-4895)
Institutions
- University of Kentucky (US)
Publication Details
- Journal
- Molecular Neurodegeneration Advances
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1186/s44477-025-00007-8
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00