Treatment of post-vaccination optic neuritis: implications from the global SARS-CoV-2 vaccination effort

What is known Post-vaccination optic neuritis (ON) was previously considered a rare, anecdotal occurrence before the COVID-19 pandemic. Retrospective database studies conducted after the pandemic identified ON as the second most common vaccine-related complication affecting vision. What is new A prospective, deeply phenotyped global cohort of post-vaccination ON was studied using a pre-specified protocol and novel consensus diagnostic criteria. Longitudinal data demonstrated excellent recovery of visual function, despite measurable atrophy in the retinal nerve fibre layer (RNFL) and ganglion cell layer (GCL) on optical coherence tomography (OCT). Evidence supports that rapid initiation of corticosteroid treatment helps preserve the RNFL and GCL, highlighting this as a treatable condition with favorable outcomes when managed promptly.

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Publication Details

Journal
Graefe s Archive for Clinical and Experimental Ophthalmology
Published
2025-11-29
DOI
https://doi.org/10.1007/s00417-025-06805-w
Primary Topic
Retinal and Optic Conditions
Type
article
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Treatment of post-vaccination optic neuritis: implications from the global SARS-CoV-2 vaccination effort

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Treatment of post-vaccination optic neuritis: implications from the global SARS-CoV-2 vaccination effort

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article en

Abstract

What is known Post-vaccination optic neuritis (ON) was previously considered a rare, anecdotal occurrence before the COVID-19 pandemic. Retrospective database studies conducted after the pandemic identified ON as the second most common vaccine-related complication affecting vision. What is new A prospective, deeply phenotyped global cohort of post-vaccination ON was studied using a pre-specified protocol and novel consensus diagnostic criteria. Longitudinal data demonstrated excellent recovery of visual function, despite measurable atrophy in the retinal nerve fibre layer (RNFL) and ganglion cell layer (GCL) on optical coherence tomography (OCT). Evidence supports that rapid initiation of corticosteroid treatment helps preserve the RNFL and GCL, highlighting this as a treatable condition with favorable outcomes when managed promptly.

Graefe s Archive for Clinical and Experimental OphthalmologyVol. 264(3)
Moorfields Eye Hospital NHS Foundation Trust (GB), University College London Hospitals NHS Foundation Trust (GB), Queen Mary University of London (GB), Guy's and St Thomas' NHS Foundation Trust (GB), Queen Elizabeth Hospital Birmingham (GB), Sandwell & West Birmingham Hospitals NHS Trust (GB), Kings Health Partners (GB), Birmingham and Midland Eye Centre (GB), National Hospital for Neurology and Neurosurgery (GB), University College London (GB)
Openalex Percentile: Top 49%
Retinal and Optic Conditions
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