CD74+CCL5+ effector CD8+ T cells drive mucosal inflammation and predict biologics response in inflammatory bowel disease
CCL5 + CD8 + T cells are profoundly enriched in IBD colonic tissues and drive mucosal inflammation through pro-inflammatory pathways. A six-gene model, particularly involving FKBP11, demonstrated potential for disease stratification and infliximab response prediction. These findings highlight immune and microbial features of IBD that merit further functional and clinical validation.
Authors
- Jiaxiong Tan (ORCID: https://orcid.org/0000-0002-5606-3962)
- Bingqing Yu (ORCID: https://orcid.org/0000-0002-9844-2573)
- Xiongxiu Liu
- Shanshan Wu (ORCID: https://orcid.org/0000-0001-9791-8093)
- Cai Zhang
- Shuangchun Liu (ORCID: https://orcid.org/0009-0003-3534-5375)
Institutions
- Tianjin Medical University Cancer Institute and Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1186/s12967-025-07509-9
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.82