Dual block evidence of the effects of topiramate, a sulfamate-substituted monosaccharide, on voltage-gated sodium current and hyperpolarization-activated cation current
Collectively, these findings strongly suggest that TPM's effects on I<sub>Na</sub> and I<sub>h</sub> have the potential to impact the functional activities and electrical behaviors of excitable cells.
Authors
- Chin‐Wei Huang (ORCID: https://orcid.org/0000-0003-3335-2187)
- Ray-Chang Tzeng
- Ming‐Chi Lai (ORCID: https://orcid.org/0000-0001-8890-0166)
- Sheng‐Nan Wu (ORCID: https://orcid.org/0000-0002-5208-3253)
Institutions
- Chi Mei Medical Center (TW)
- Tainan Municipal Hospital (TW)
- National Cheng Kung University Hospital (TW)
Publication Details
- Journal
- BMC Pharmacology and Toxicology
- Published
- 2025-11-29
- DOI
- https://doi.org/10.1186/s40360-025-01043-6
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 0.00